Featured Articles

Brain microenvironment-remodeling nanomedicine improves cerebral glucose metabolism, mitochondrial activity and synaptic function in a mouse model of alzheimer’s disease.

Biomaterials, 2025

Catechol-based chemistry for hypoglycemia-responsive delivery of zinc-glucagon via hydrogel-based microneedle patch technology.

Nature Communications, 2025

Glucose‐Responsive Composite Microneedle Patch for Hypoglycemia‐Triggered Delivery of Native Glucagon

Advanced Materials 2019

Publications

2021
2020
​2019
​2018
2017
2016
2015
2009 to 2014
2008 and earlier

2025

  1. GhavamiNejad, A., Liu, J.F., Mirzaie, S. et al. Catechol-based chemistry for hypoglycemia-responsive delivery of zinc-glucagon via hydrogel-based microneedle patch technology. Nat Commun 16, 3124 (2025). https://doi.org/10.1038/s41467-025-58278-4
  2. Park, E., He, C., Abbasi, A. Z., Tian, M., Huang, S., Wang, L., Georgiou, J., Collingridge, G. L., Fraser, P. E., Henderson, J. T., & Wu, X. Y., 2025. Brain microenvironment-remodeling nanomedicine improves cerebral glucose metabolism, mitochondrial activity and synaptic function in a mouse model of alzheimer’s disease. Biomaterials, 318, 123142. 
  3. Alradwan, I., Zhi, P., Zhang, T., Lip, H., Zetrini, A., He, C., Henderson, J. T., Rauth, A. M., & Wu, X. Y., 2025. Nanoparticulate Drug Combination inhibits DNA damage repair and PD-L1 expression in BRCA-mutant and wild type triple-negative breast cancer. Journal of Controlled Release, 377, 661–674. https://doi.org/10.1016/j.jconrel.2024.11.061 

2024

  1. Chen, K., Chang, H. H., Lugtu-Pe, J., Gao, Y., Liu, F.-C., Kane, A., & Wu, X. Y., 2024. Exploration of a novel terpolymer nanoparticle system for the prevention of alcohol-induced dose dumping. Molecular Pharmaceutics, 21(12), 6257–6269. https://doi.org/10.1021/acs.molpharmaceut.4c00706 
  2. Zetrini, A. E., Abbasi, A. Z., He, C., Lip, H., Alradwan, I., Rauth, A. M., Henderson, J. T., & Wu, X. Y., 2024. Targeting DNA damage repair mechanism by using RAD50-silencing Sirna nanoparticles to enhance radiotherapy in triple negative breast cancer. Materials Today Bio, 28, 101206. https://doi.org/10.1016/j.mtbio.2024.101206 
  3. Li, L. Y., Park, E., He, C., Abbasi, A. Z., Henderson, J. T., Fraser, P. E., Uetrecht, J. P., Rauth, A. M., & Wu, X. Y., 2024. Evaluation of the biodistribution and preliminary safety profile of a novel brain-targeted manganese dioxide-based nanotheranostic system for alzheimer’s disease. Nanotoxicology, 1–20. https://doi.org/10.1080/17435390.2024.2361687 
  4. Lugtu-Pe, J. A., Zhang, X., Mirzaie, S., Chang, H. H., AL-Mousawi, N., Chen, K., Li, Y., Kane, A., Bar-Shalom, D., & Wu, X. Y., 2024. An emerging terpolymeric nanoparticle pore former as an internal recrystallization inhibitor of celecoxib in controlled release amorphous solid dispersion beads: Experimental Studies and Molecular Dynamics Analysis. Acta Pharmaceutica Sinica B, 14(6), 2669–2684. https://doi.org/10.1016/j.apsb.2024.03.026  
  5. Yen T.Y., Abbasi A.Z., He C., Lip H.Y., Park E., Amini M.A., Adissu H.A., Foltz W., Rauth A.M., Henderson J., Wu X.Y., 2024. Biocompatible and bioactivable terpolymer-lipid-MnO2 Nanoparticle-based MRI contrast agent for improving tumor detection and delineation. Materials Today Bio. https://doi.org/10.1016/j.mtbio.2024.100954
  6. Ahmed, T., Liu, F.-C. F., & Wu, X. Y., 2024. An update on strategies for optimizing polymer-lipid hybrid nanoparticle-mediated drug delivery: Exploiting transformability and bioactivity of PLN and harnessing intracellular lipid transport mechanism. Expert Opinion on Drug Delivery, 21(2), 245–278. https://doi.org/10.1080/17425247.2024.2318459 
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2023

  1. Zetrini, A. E., Lip, H., Abbasi, A. Z., Alradwan, I., Ahmed, T., He, C., Henderson, J. T., Rauth, A. M., & Wu, X. Y., 2023. Remodeling tumor immune microenvironment by using polymer-lipid-manganese dioxide nanoparticles with radiation therapy to boost immune response of castration-resistant prostate cancer. Research, 6. https://doi.org/10.34133/research.0247 
  2. Liu, J.F., GhavamiNejad, A., Lu, B., Mirzaie ,S., Samarikhalaj, M., Giacca, A., Wu, XY., 2023. “Smart” matrix Microneedle Patch made of self-crosslinkable and multifunctional polymers for delivering insulin on-demand. Advanced science.  https://doi.org/10.1002/advs.202303665
  3. Park, E., Li, L.Y., He, C., Abbasi, A.Z., Ahmed, T., Foltz, W.D., O'Flaherty, R., Zain, M., Bonin, R.P., Rauth, A.M., Fraser, P.E., Henderson, J.T., Wu, X.Y., 2023. Brain‐penetrating and disease site‐targeting manganese dioxide‐polymer‐lipid hybrid nanoparticles remodel microenvironment of alzheimer's disease by regulating multiple pathological pathways. Advanced Science. https://doi.org/10.1002/advs.202207238
  4. Chang, H.H.R., Chen, K., Lugtu-Pe, J.A., AL-Mousawi, N., Zhang, X., Bar-Shalom, D., Kane, A., Wu, X.Y., 2023. Design and optimization of a nanoparticulate pore former as a multifunctional coating excipient for ph transition-independent controlled release of weakly basic drugs for oral drug delivery. Pharmaceutics 2023, 15(2), 547; https://doi.org/10.3390/pharmaceutics15020547

2022

  1. Ahmed, T., Liu, F.-C.F., Lu, B., Lip, H.Y., Park, E., Alradwan, I., Liu, J.F., He, C., Zetrini, A., Zhang, T., Ghavaminejad, A., Rauth, A.M., Henderson, J.T., Wu, X.Y., 2022. Advances in nanomedicine design: Multidisciplinary strategies for unmet medical needs. Molecular Pharmaceutics 19, 1722–1765. doi:10.1021/acs.molpharmaceut.2c00038                                                                                                    
  2. Lu, B., GhavamiNejad, A., Liu, F. L., Li, J., Mirzaie, S., Giacca, A., Wu, X.Y., 2022: “Smart” Composite Microneedle Patch Stabilizes Glucagon and Prevents Nocturnal Hypoglycemia: Experimental Studies and Molecular Dynamics Simulation. ACS Appl. Mater. Interfaces. https://doi.org/10.1021/acsami.1c24955
  3. Lip, H.Y., Amini, M.A., Zetrini, A., Cai, P., Abbasi, A.Z., Bristow, R.G., Rauth, A.M., Wu, X.Y., 2022. Redox-responsive nanoparticles enhance radiation therapy by altering multifaceted radio-resistance mechanisms in human castration-resistant prostate cancer cells and xenografts. Radiotherapy and Oncology. https://doi.org/10.1016/j.radonc.2022.02.026
  4. Zhang, R. X., Liu, F. F.-C., Lip, H., Liu, J., Zhang, Q., & Wu, X. Y., 2022. Pharmaceutical nanoformulation strategies to spatiotemporally manipulate oxidative stress for improving cancer therapies — exemplified by polyunsaturated fatty acids and other ROS-modulating agents. Drug Delivery and Translational Research. https://doi.org/10.1007/s13346-021-01104-3 ​
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2021

  1. Lugtu-Pe, J.A., Lin, B.Y., Chen, K., Ghaffari, A., Kane, A., Wu, X.Y., 2021. Tailoring Release Profiles of BCS Class II Drugs Using Controlled Release Amorphous Solid Dispersion Beads with Membrane-Reservoir Design: Effect of Pore Former and Coating Levels. Molecular Pharmaceutics. https://pubs.acs.org/doi/full/10.1021/acs.molpharmaceut.1c00623 
  2. Ahmed, T., Liu, F.-C.F., He, C., Abbasi, A.Z., Cai, P., Rauth, A.M., Henderson, J.T., Wu, X.Y., 2021. Optimizing the design of blood–brain barrier-penetrating polymer-lipid-hybrid nanoparticles for delivering anticancer drugs to glioblastoma. Pharmaceutical Research. doi:10.1007/s11095-021-03122-9 
  3. Zhang, R.X., Dong, K., Wang, Z., Miao, R., Lu, W., Wu, X.Y., 2021. Nanoparticulate Drug Delivery Strategies to address intestinal cytochrome P450 CYP3A4 metabolism towards personalized medicine. Pharmaceutics 13, 1261. doi:10.3390/pharmaceutics13081261 
  4. Zhang, T., Fu, C., Alradwan, I., Yen, T.Y., Lip, H.Y., Cai, P., Rauth, A.M., Zhang, L., Wu, X.Y., 2021. Targeting signaling pathways of hyaluronic acid and integrin receptors by synergistic combination nanocomposites inhibits systemic metastases and primary triple negative breast cancer. Advanced Therapeutics 4, 2100022. doi:10.1002/adtp.202100022
  5. Mirzaie, S., Abdi, F., GhavamiNejad, A., Lu, B., Wu, X.Y., 2021. Covalent Antiviral Agents, in: Antiviral Drug Discovery and Development. Springer, Singapore, pp. 285–312. ISBN: 978-981-16-0268-9
  6. Amini, M. A., Ahmed, T., Liu, F.-C. F., Abbasi, A. Z., Soeandy, C. D., Zhang, R.X., Prashad, P., Cummins, C. L., Rauth, A. M., Henderson, J. T., Wu, X.Y. 2021. Exploring the transformability of polymer-lipid hybrid nanoparticles and nanomaterial-biology interplay to facilitate tumor penetration, cellular uptake and intracellular targeting of anticancer drugs. Expert Opinion on Drug Delivery, 1–14. https://doi.org/10.1080/17425247.2021.1902984 
  7. GhavamiNejad, A., Lu, B., Samarikhalaj, M., Liu, J. F., Mirzaie, S., Pereira, S., Zhou, L., Giacca, A., Wu, X. Y. 2021. Transdermal delivery of a somatostatin receptor type 2 antagonist using microneedle patch technology for hypoglycemia prevention. Drug Delivery and Translational Research. doi:10.1007/s13346-021-00944-3
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2020

  1. He, C., Ahmed, T., Abbasi, A.Z., Li, L.Y., Foltz, W.D., Cai, P., Knock, E., Fraser, P.E., Rauth, A.M., Henderson, J.T., Wu, X.Y., 2020. Multifunctional bioreactive-nanoconstructs for sensitive and accurate MRI of cerebrospinal fluid pathology and intervention of Alzheimer's disease. Nanotoday, doi:10.1016/j.nantod.2020.100965.
  2. Ghavaminejad, A., Ashammakhi, N., Wu, X.Y., Khademhosseini, A., 2020. Crosslinking Strategies for 3D Bioprinting of Polymeric Hydrogels. Small 16, 2002931. doi:10.1002/smll.202002931 
  3. Liu, H., Yang, Z., Lu, W., Chen, Z., Chen, L., Han, S., Wu, X., Cai, T., Cai, Y., 2020. Chemokines and chemokine receptors: A new strategy for breast cancer therapy. Cancer Medicine 9, 3786–3799. doi:10.1002/cam4.3014 

2019
  1. Zhang, T., Lip, H., He, C., Cai, P., Wang, Z., Henderson, J.T., Rauth, A.M., Wu, X.Y., 2019 Multitargeted Nanoparticles Deliver Synergistic Drugs across the Blood–Brain Barrier to Brain Metastases of Triple Negative Breast Cancer Cells and Tumor‐Associated Macrophages. Advanced Healthcare Materials.
  2. Thombre, A.G., Wu, X.Y.S., Ende, M.T.A., 2019. Controlled Release Technology And Design Of Oral Controlled Release Dosage Forms. Chemical Engineering in the Pharmaceutical Industry: Drug Product Design, Development, and Modeling, 2nd Edition, 381–407. doi:10.1002/9781119600800.ch65
  3. GhavamiNejad, A., Lu, B., Giacca, A., Wu, X.Y., 2019. Glucose regulation by modified boronic acid-sulfobetaine zwitterionic nanogels – a non-hormonal strategy for the potential treatment of hyperglycemia. Nanoscale. 10167-10171. doi:10.1039/C9NR01687B
  4. GhavamiNejad, A., Li, J., Lu, B., Zhou, L., Lam, L., Giacca, A., Wu, X.Y., 2019. Glucose‐Responsive Composite Microneedle Patch for Hypoglycemia‐Triggered Delivery of Native Glucagon. Advanced Materials.
  5. Alves, S.R., Colquhoun, A., Wu, X.Y., Silva, D.de O., 2019. Synthesis of terpolymer-lipid encapsulated diruthenium(II,III)-anti-inflammatory metallodrug nanoparticles to enhance activity against glioblastoma cancer cells. Journal of Inorganic Biochemistry.
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2018
  1. Wang, Z., Zhang, R.X., Zhang, T., He, C., He, R., Ju, X., Wu, X.Y., 2018. In Situ Proapoptotic Peptide-Generating Rapeseed Protein-Based Nanocomplexes Synergize Chemotherapy for Cathepsin-B Overexpressing Breast Cancer. ACS Applied Materials & Interfaces. doi:10.1021/acsami.8b14001
  2. Amini, M.A., Abbasi, A.Z., Cai, P., Lip, H., Gordijo, C.R., Li, J., Chen, B., Zhang, L., Rauth, A.M., Wu, X.Y., 2018. Combining Tumor Microenvironment Modulating Nanoparticles with Doxorubicin to Enhance Chemotherapeutic Efficacy and Boost Antitumor Immunity. JNCI: Journal of the National Cancer Institute. doi:10.1093/jnci/djy131
  3. Lugtu-Pe, J.A., Ghaffari, A., Chen, K., Kane, A., Wu, X.Y., 2018. Development of controlled release amorphous solid dispersions (CRASD) using polyvinyl acetate-based release retarding materials: Effect of dosage form design. European Journal of Pharmaceutical Sciences 124, 319–327. doi:10.1016/j.ejps.2018.09.006
  4. Zhang, R.X., Li, J., Zhang, T., Amini, M.A., He, C., Lu, B., Ahmed, T., Lip, H., Rauth, A.M., Wu, X.Y., 2018. Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy – An illustration with firsthand examples. Acta Pharmacologica Sinica. doi:10.1038/aps.2018.33
  5. He, C., Li, J., Cai, P., Ahmed, T., Henderson, J.T., Foltz, W.D., Bendayan, R., Rauth, A.M., Wu, X.Y., 2018. Two-Step Targeted Hybrid Nanoconstructs Increase Brain Penetration and Efficacy of the Therapeutic Antibody Trastuzumab against Brain Metastasis of HER2-Positive Breast Cancer. Advanced Functional Materials 1705668. doi:10.1002/adfm.201705668
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2017
  1. Chen, K., Chang, H.H.R., Shalviri, A., Li, J., Lugtu-Pe, J.A., Kane, A., Wu, X.Y., 2017. Investigation of a New pH-responsive Nanoparticulate Pore Former for Controlled Release Enteric Coating with Improved Processability and Stability. European Journal of Pharmaceutics and Biopharmaceutics. doi:10.1016/j.ejpb.2017.08.014
  2. Zhang, R., Zhang, T., Chen, K., Cheng, J., Lai, P., Rauth, A.M., Pang, K.S., Wu, X.Y. 2017. Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-Bearing Mice. Journal of Visualized Experiments.
  3. ​Rico, S.R.A., Abbasi, A.Z., Ribeiro, G., Ahmed, T., Wu, X.Y., Silva, D.D.O., 2017. Diruthenium(II,III) metallodrugs of ibuprofen and naproxen encapsulated in intravenously injectable polymer-lipid nanoparticles exhibit enhanced activity against breast and prostate cancer cells. Nanoscale. doi:10.1039/c7nr01582h
  4. Zhang, R.X., Li, L.Y., Li, J., Xu, Z., Abbasi, A.Z., Lin, L., Amini, M.A., Weng, W.Y., Sun, Y., Rauth, A.M., Wu, X.Y., (2017). Coordinating Biointeraction and Bioreaction of a Nanocarrier Material and an Anticancer Drug to Overcome Membrane Rigidity and Target Mitochondria in Multidrug-Resistant Cancer Cells. Advanced Functional Materials. doi:10.1002/adfm.201700804
  5. Li, Jason, Michael K. Chu, Brian Lu, Sako Mirzaie, Kuan Chen, Claudia R. Gordijo, Oliver Plettenburg, Adria Giacca, and Xiao Yu Wu. (2017) Enhancing thermal stability of a highly concentrated insulin formulation with Pluronic F-127 for long-term use in microfabricated implantable devices. Drug Delivery and Translational Research, doi:10.1007/s13346-017-0381-8.
  6. Zhang, T., Prasad, P., Cai, P., He, C., Shan, D., Rauth, A. M., & Wu, X. Y. (2017). Dual-targeted hybrid nanoparticles of synergistic drugs for treating lung metastases of triple negative breast cancer in mice. Acta Pharmacologica Sinica. doi:10.1038/aps.2016.166
  7. He, C., Cai, P., Li, J., Zhang, T., Lin, L., Abbasi, A. Z.,Wu, X. Y. (2017). Blood-brain barrier-penetrating amphiphilic polymer nanoparticles deliver docetaxel for the treatment of brain metastases of triple negative breast cancer. Journal of Controlled Release, 246, 98-109. doi:10.1016/j.jconrel.2016.12.019
  8. Zhang, R. X., Ahmed, T., Li, L. Y., Li, J., Abbasi, A. Z., & Wu, X. Y. (2017). Design of nanocarriers for nanoscale drug delivery to enhance cancer treatment using hybrid polymer and lipid building blocks. Nanoscale, 9(4), 1334-1355. doi:10.1039/c6nr08486a
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2016
  1. Abbasi, A. Z., Gordijo, C. R., Amini, M. A., Maeda, A., Rauth, A. M., Dacosta, R. S., & Wu, X. Y. (2016). Hybrid Manganese Dioxide Nanoparticles Potentiate Radiation Therapy by Modulating Tumor Hypoxia. Cancer Research, 76(22), 6643-6656. doi:10.1158/0008-5472.can-15-3475
  2. Zhou, Y., He, C., Chen, K., Ni, J., Cai, Y., Guo, X., & Wu, X. Y. (2016). A New Method for Evaluating Actual Drug Release Kinetics of Nanoparticles inside Dialysis Devices via Numerical Deconvolution. Journal of Controlled Release, 243, 11-20. doi:10.1016/j.jconrel.2016.09.031
  3. Amini, M. A., Abbasi, A. Z., Gordijo, C. R., Cai, P., Rauth, A. M., Bristow, R. G., & Wu, X. Y. (2016). Abstract 745: Hybrid bioactive nanoparticles for modulating prostate tumor microenvironment and enhancing radiation therapy. Cancer Research, 76(14 Supplement), 745-745. doi:10.1158/1538-7445.am2016-745
  4. Zhang, R. X., Wong, H. L., Xue, H. Y., Eoh, J. Y., & Wu, X. Y. (2016). Nanomedicine of synergistic drug combinations for cancer therapy – Strategies and perspectives. Journal of Controlled Release, 240, 489-503. doi:10.1016/j.jconrel.2016.06.012
  5. Wu, X. Y. (2016). Strategies for optimizing polymer-lipid hybrid nanoparticle-mediated drug delivery. Expert Opinion on Drug Delivery, 13(5), 609-612. doi:10.1517/17425247.2016.1165662
  6. Ma, Y., Wang, Q., Gong, J., & Wu, X. Y. (2016). Formulation of Granules for Site-Specific Delivery of an Antimicrobial Essential Oil to the Animal Intestinal Tract. Journal of Pharmaceutical Sciences, 105(3), 1124-1133. doi:10.1016/j.xphs.2015.10.001
  7. Huang, Y., Cai, T., Xia, X., Cai, Y., & Wu, X. Y. (2016). Research Advances in the Intervention of Inflammation and Cancer by Active Ingredients of Traditional Chinese Medicine. Journal of Pharmacy & Pharmaceutical Sciences, 19(1), 114. doi:10.18433/j3sg7k
  8. R.X. Zhang, P. Cai, T. Zhang, K. Chen, J. Li, J. Cheng, K.S. Pang, A.M Rauth, X.Y. Wu,  (2016). Polymer-lipid hybrid nanoparticles synchronize pharmacokinetics of co-encapsulated doxorubicin-mitomycin C and enable their spatiotemporal co-delivery and local bioavailability in breast tumor, Nanomedicine.
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2015
  1. Y. Li, N. Taulier, M.R. Abbaspour, P. Grootenrst, A.M. Rauth, X.Y. Wu, Optimization of controlled release nanoparticle formulation of verapamil hydrochloride using artificial neural networks with genetic algorithm and response surface methodology, Eur J Pharm Biopharm. 2015, 94, 170-179
  2. J. Chen, J. Li, C. Gordijo, M. Chu, Y. Sun, X.Y. Wu, Stimuli-Responsive Drug Delivery Microchips, in Encyclopedia of Nanotechnology (2nd ed), Chapter ID 390, 2015
  3. Y-H. Ma, Q. Wang, J. Gong, X.Y. Wu, Formulation of granules for site-specific delivery of antimicrobial essential oil to the animal GI tract, J. Pharm. Sci. 2015
  4. A.Z. Abbasi, P. Prasad, P. Cai, C. He, W.D. Foltz, M.A. Amini, C.R. Gordijo, A.M. Rauth, X.Y. Wu, Manganese oxide and docetaxel co-loaded fluorescent polymer nanoparticles for dual modal imaging and chemotherapy of breast cancer, J. Control. Release 2015, 209, 186-196.
  5. J. Cheng, Q. Liu, A.J. Shuhendler, A.M. Rauth, X. Y. Wu, Optimizing the Design and In Vitro Evaluation of Bioreactive Glucose Oxidase-Microspheres for Enhanced Cytotoxicity against Multidrug Resistant Breast Cancer Cells, Colloids Surf. B Biointerfaces 2015, 1(130),164-172.
  6. C. Gordijo, X.Y. Wu, A new life to an old material, Materials Today 2015
  7. C. Gordijo*, A.Z. Abbasi*, M.A. Amini, H.Y. Lip, A. Maeda, P. Cai, P.J. O?Brien, R.S. DaCosta, A.M. Rauth , X.Y. Wu, Design of hybrid MnO2-polymer-lipid nanoparticles with tunable oxygen generation rate and tumor accumulation for cancer treatment, Adv Func Mater. 10.1002/adfm.201404511 (Frontispiece and editorial highlight)
  8. J. Li, M. K.L. Chu, C. R. Gordijo, A. Z. Abbasi, K. Chen, H. A. Adissu, A. Giacca, O. Plettenburg, M. Lohn, X.Y. Wu, Microfabricated microporous membranes reduce the host immune response and prolong the functional lifetime of a closed-loop insulin delivery implant in a type 1 diabetic rat model, Biomaterials 2015, 47, 51-61.
  9. M. K.L. Chu, C. R. Gordijo, J. Li, A. Z. Abbasi, A. Giacca, O. Plettenburg, X.Y. Wu, In Vivo Performance and Biocompatability of a Subcutaneous Implant for Real-Time Glucose-Responsive Insulin Delivery, Diabetes Technology & Therapeutics 2015, DOI 10.1089/dia.2014.0229
  10. D. Shan, J. Li, P. Cai, P. Prasad, F. Liu, A. M. Rauth, X. Y. Wu, RGD-conjugated solid lipid nanoparticles inhibit adhesion and invasion of αvβ3 integrin-overexpressing breast cancer cellls, Drug Delivery and Translational Research 2015, Drug Delivery and Translational Research, 5(1), 15-26.
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2009 to 2014
  1. ​M. J. Abdekhodaie, J. Cheng, X.Y. Wu, Effect of Formulation Factors on the Bioactivity of Glucose Oxidase Encapsulated Chitosan-Alginate Microspheres: In Vitro Investigation and Mathematical Model Prediction, Chemical Engineering Science 2014, 124, 4-12.
  2. J. Li*, P. Cai*, A. Shalviri*, J. T. Henderson, C. He, W. D. Foltz, P. Prasad, P. M. Broderson, Y. Chen, R. DaCosta, A. M. Rauth, X. Y. Wu, A Multifunctional Polymeric Nanotheranostic System Delivers Doxorubicin and Imaging Agents across the Blood–Brain Barrier Targeting Brain Metastases of Breast Cancer, ACS Nano 2014, 8(10), 9925-9940.
  3. P. Prasad*, C. R. Gordijo*, A. Z. Abbasi, A. Maeda, A. Ip, A. M. Rauth, R. S. DaCosta, X. Y. Wu, Multifunctional Albumin-MnO2 Nanoparticles Modulate Solid Tumor Microenvironment by Attenuating Hypoxia, Acidosis, Vascular Endothelial Growth Factor and Enhance Radiation Response, ACS Nano 2014, 8(6), 3202-3212.
  4. A. J. Shuhendler*, P. Prasad*, R. X. Zhang*, M. Amini, M. Sun, P. Liu, R. G. Bristow, A. M. Rauth, X. Y. Wu, Synergistic Nanoparticulate Drug Combination Overcomes Multidrug Resistance, Increases Efficacy, and Reduces Cardiotoxicity in a Nonimmunocompromised Breast Tumor Model, Molecular Pharmaceutics 2014, 11(8), 2659-2674.
  5. A. J. Shuhendler, P. Prasad, P. Cai, K. K.W. Hui, J. T. Henderson, A. M. Rauth, X. Y. Wu, Matrigel alters the pathophysiology of orthotopic human breast adenocarcinoma xenografts with implications for nanomedicine evaluation, Nanomedicine: Nanotechnology, Biology and Medicine 2013, 9(6), 957-805.
  6. Preethy Prasad, Adam Shuhendler, Ping Cai, Andrew M Rauth, Xiao Yu Wu, Doxorubicin and mitomycin C co-loaded polymer-lipid hybrid nanoparticles inhibit growth of sensitive and multidrug resistant human mammary tumor xenografts, Cancer Letters 2013, 334(2), 263-273.
  7. Alireza Shalviri, Warren D Foltz, Ping Cai, Andrew M Rauth, Xiao Yu Wu, Multifunctional terpolymeric MRI contrast agent with superior signal enhancement in blood and tumor, J. Control. Release 2013, 167(1), 11-20.
  8. A. Shalviri, P. Cai, A. M. Rauth, J. T. Henderson, X. Y. Wu, Evaluation of new bi-functional terpolymeric nanoparticles for simultaneous in vivo optical imaging and chemotherapy of breast cancer, Drug Delivery and Translational Research (2012) 2, 6, 437-453.
  9. Alireza Shalviri, Ho Ka Chan, Gaurav Raval, Mohammad J Abdekhodaie, Qiang Liu, Heiko Heerklotz, Xiao Yu Wu, Design of pH-responsive nanoparticles of terpolymer of poly (methacrylic acid), polysorbate 80 and starch for delivery of doxorubicin, Colloids and Surfaces B: Biointerfaces 2013, 101, 405-413.
  10. Alireza Shalviri, Gaurav Raval, Preethy Prasad, Carol Chan, Qiang Liu, Heiko Heerklotz, Andrew Michael Rauth, Xiao Yu W, pH-Dependent doxorubicin release from terpolymer of starch, polymethacrylic acid and polysorbate 80 nanoparticles for overcoming multi-drug resistance in human breast cancer cells, European J. of Pharmaceutics and Biopharmaceutics 2012, 82(3), 587-597.
  11. A. J. Shuhendler, P. Prasad, M. Leung, A. M. Rauth, R. S. DaCosta, X.Y. Wu (2012) A novel solid lipid nanoparticle formulation for active targeting to tumor α(v) β(3) integrin receptors reveals cyclic RGD as a double-edged sword, Adv. Healthcare Materials, (2012) 1(5):600-8. 
  12. M. K.L. Chu, J. Chen, C. R. Gordijo, K. Koulajian, S. Chiang, A. Ivovic, A. Giacca, X. Yu Wu and Y. Sun (2012)  
    In Vivo Performance of Polydimethylsiloxane (PDMS) Grid-Bioinorganic Gel Microdevices in Glucose-Responsive Treatment of Diabetic Rats, Lab On a Chip (2012) 12, 2533–2539.
  13. P. Prasad, J. Cheng, A.J. Shuhendler, A.M. Rauth, X.Y. Wu  A novel nanoparticle formulation overcomes multiple types of membrane efflux pumps in human breast cancer cells, Drug Delivery and Translational Research (2012) Volume 2, Number 2, 95-105. 
  14. A.J. Shuhendler, P. Prasad, H-K. Chan, C.R. Gordijo, B. Saroushian, M. Kolios, K. Yu, P.J. O’Brien, A.M. Rauth, and X.Y. Wu Hybrid quantum dot-fatty ester stealth nanoparticles: Toward clinically relevant in vivo optical imaging of deep tissue, ACS Nano (2011) 5 (3) 1958–1966 
  15. A.J. Shuhendler, R. Staruch, W. Oakden, C.R. Gordijo, A.M. Rauth, G.J. Stanisz, R. Chopra, X.Y. Wu Thermally-triggered ‘off-on-off’ response of gadolinium-hydrogel-lipid hybrid nanoparticles defines a customizable temperature window for non-invasive MRI thermometry,  J. Control. Release  (2012) 157(3):478-84.  
  16. Wong H.L., Wu X.Y., Bendayan R. (2011) Nanotechnological advances for the delivery of CNS therapeutics, Advanced Drug. Delivery Reviews (2012) volume 64, 7, 686–700.
  17. Henderson E.J., Shuhendler A.J., Prasad P.,Baumann V., Maier-Flaig F., Lemmer U., Wu X.Y., Ozin G.A. Colloidally-stable silicon nanocrystals with near-infrared photoluminescence for biological fluorescence imaging, Small, (2011) 7, 17, 2507–2516. 
  18. Jian Chen, Yi Zheng, Qingyuan Tan, Ehsan Shojaei-Baghini, Yan Liang Zhang, Jason Li, Preethy Prasad, Lidan You, X.Y. Wu, and Yu Sun, Classification of cell types using a microfluidic device for mechanical and electrical measurement on single cells, Lab-On-A Chip, (2011) 11, 3174-3181.
  19. Gordijo, C. R., Koulajian, K., Shuhendler, A. J., Bonifacio, L. D., Huang, H. Y., Chiang, S., Ozin G.A., Giacca A., Wu X.Y. Nanotechnology-enabled closed loop insulin delivery device: In vitro and in vivo evaluation of glucose-regulated insulin release for diabetes control. Advanced Functional Materials, (2011) 21(1), 73-82.
  20. Shuhendler, A. J., Gordijo, C. R., Staruch, R., Oakden, W., Stanisz, G., Chopra, R., Wu, X.Y. (2010). Gadolinium-hydrogel-lipid hybrid nanoparticles provide 'off-on-off' MRI signals for non-invasive thermometry. Materials Research Society Symposium Proceedings, 1241 66-72. 
  21. Liu, Q., Shuhendler, A., Cheng, J., Rauth, A. M., O'Brien, P., & Wu, X. Y. Cytotoxicity and mechanism of action of a new ROS-generating microsphere formulation for circumventing multidrug resistance in breast cancer cells. Breast Cancer Research and Treatment, (2010) 121(2), 323-333. 
  22. Gordijo, C. R., Shuhendler, A. J., & Wu, X. Y. Glucose-responsive bioinorganic nanohybrid membrane for self-regulated insulin release. Advanced Functional Materials, (2010) 20(9), 1404-1412. 
  23. Wong, H. L., Chattopadhyay, N., Wu, X. Y., & Bendayan, R. (2010). Nanotechnology applications for improved delivery of antiretroviral drugs to the brain. Advanced Drug Delivery Reviews, 62(4-5), 503-517. 
  24. Shalviri, A., Liu, Q., Abdekhodaie, M. J., & Wu, X. Y. (2010). Novel modified starch-xanthan gum hydrogels for controlled drug delivery: Synthesis and characterization. Carbohydrate Polymers, 79(4), 898-907. 
  25. Zhou, Y., Chu, J. S., Li, J. X., & Wu, X. Y. (2010). Theoretical analysis of release kinetics of coated tablets containing constant and non-constant drug reservoirs. International Journal of Pharmaceutics, 385(1-2), 98-103. 
  26. Kim, K., Cheng, J., Liu, Q., Wu, X. Y., & Sun, Y. (2010). Investigation of mechanical properties of soft hydrogel microcapsules in relation to protein delivery using a MEMS force sensor. Journal of Biomedical Materials Research - Part A, 92(1), 103-113. 
  27. Shuhendler, A. J., Cheung, R. Y., Manias, J., Connor, A., Rauth, A. M., & Wu, X. Y. (2010). A novel doxorubicin-mitomycin C co-encapsulated nanoparticle formulation exhibits anti-cancer synergy in multidrug resistant human breast cancer cells. Breast Cancer Research and Treatment, 119(2), 255-269. 
  28. A.G. Thombre, M.T. am Ende, X.Y. Wu, (2010) Design of oral controlled release dosage forms, in: Chemical Engineering in the Pharmaceutical Industry: From R&D to Manufacturing, ed. D.J. am Ende (on invitation), Wiley and AIChE, pp.703-726. 
  29. Chen, J., Chu, M., Koulajian, K., Wu, X. Y., Giacca, A., & Sun, Y. (2009). pH-responsive drug-delivery devices for implantable applications. Paper presented at the TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems, 1465-1468. 
  30. Chen, J., Chu, M., Koulajian, K., Wu, X. Y., Giacca, A., & Sun, Y. (2009). A monolithic polymeric microdevice for pH-responsive drug delivery. Biomedical Microdevices, 11(6), 1251-1257. 
  31. Kim, K., Liu, X., Zhang, Y., Cheng, J., Wu, X. Y., & Sun, Y. (2009). Manipulation at the nanonewton level: Micrograpsing for mechanical characterization of biomaterials. Paper presented at the Proceedings - IEEE International Conference on Robotics and Automation, 902-907. 
  32. Liu, Q., Rauth, A. M., Liu, J., Babakhanian, K., Wang, X., Bendayan, R., et al. (2009). Characterization of a microsphere formulation containing glucose oxidase and its in vivo efficacy in a murine solid tumor model. Pharmaceutical Research, 26(10), 2343-2357. 
  33. Wong H.L., Wu X.Y., Bendayan R. (2009) Multidrug resistance in solid tumor and its reversal, in: Y. Lu, R.I. Mahato (Eds.) Pharmaceutical Aspects of Cancer Chemotherapy (on invitation), Springer New York, pp. 121-148.
  34. Abdekhodaie, M. J., & Wu, X. Y. (2009). Modeling of a glucose sensitive composite membrane for closed-loop insulin delivery. Journal of Membrane Science, 335(1-2), 21-31. 
  35. Liu, J., Meisner, D., Kwong, E., Wu, X. Y., & Johnston, M. R. (2009). Translymphatic chemotherapy by intrapleural placement of gelatin sponge containing biodegradable paclitaxel colloids controls lymphatic metastasis in lung cancer. Cancer Research, 69(3), 1174-1181.
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2008 and earlier
  1. Liu, J., Scollard, D. A., Reilly, R. M., Wu, X. Y., & Johnston, M. R. (2008). Effect of particle size on the lymphatic distribution of 111Indium-aminopolystyrene through intrapleural administration. Lymphology, 41(4), 153-160. 
  2. Kim, K., Liu, X., Zhang, Y., Cheng, J., Wu, X. Y., & Sun, Y. (2008). Mechanical characterization of polymeric microcapsules using a force-feedback MEMS microgripper. Paper presented at the Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology", 1845-1848.
  3. Kim, K., Liu, X., Zhang, Y., Cheng, J., Wu, X. Y., & Sun, Y. (2008). Mechanical characterization of polymeric microcapsules using a force-feedback MEMS microgripper. Conference Proceedings : ...Annual International Conference of the IEEE Engineering in Medicine and Biology Society.IEEE Engineering in Medicine and Biology Society.Conference, 2008, 1845-1848. 
  4. Chattopadhyay, N., Zastre, J., Wong, H. -., Wu, X. Y., & Bendayan, R. (2008). Solid lipid nanoparticles enhance the delivery of the HIV protease inhibitor, atazanavir, by a human brain endothelial cell line. Pharmaceutical Research, 25(10), 2262-2271. 
  5. Kim, K., Cheng, J., Liu, Q., Wu, X. Y., & Sun, Y. (2008). MEMS capacitive force sensors for micro-scale compression testing of biomaterials. Paper presented at the Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), 888-891. 
  6. Li, Y., Wong, H. L., Shuhendler, A. J., Rauth, A. M., & Wu, X. Y. (2008). Molecular interactions, internal structure and drug release kinetics of rationally developed polymer-lipid hybrid nanoparticles. Journal of Controlled Release, 128(1), 60-70.  
  7. Huang, H. Y., Shaw, J., Yip, C., & Wu, X. Y. (2007). Microdomain pH gradient and kinetics inside composite polymeric membranes of pH and glucose sensitivity. Pharmaceutical Research, 25(5), 1150-1157. 
  8. A.J. Shuhendler, P. O’Brien, A.M. Rauth, X.Y. Wu (2008) On the synergistic effect of doxorubicin and mitomycin C against breast cancer cells, Drug Metabolism and Drug Interactions, 22 (4), 201-233.
  9. Abdekhodaie, M. J., & Wu, X. Y. (2008). Drug release from ion-exchange microspheres: Mathematical modeling and experimental verification. Biomaterials, 29(11), 1654-1663. 
  10. Moselhy, J., Sarkar, S., Chia, M. C., Mocanu, J. D., Taulier, N., Liu, F. F., et al. (2007). Evaluation of copolymers of N-isopropylacrylamide and 2-dimethyl(aminoethyl)methacrylate in nonviral and adenoviral vectors for gene delivery to nasopharyngeal carcinoma. International Journal of Nanomedicine, 2(3), 461-478. 
  11. Liu, Q., Rauth, A. M., & Wu, X. Y. (2007). Immobilization and bioactivity of glucose oxidase in hydrogel microspheres formulated by an emulsification-internal gelation-adsorption-polyelectrolyte coating method. International Journal of Pharmaceutics, 339(1-2), 148-156. 
  12. Wong, H. L., Bendayan, R., Rauth, A. M., Li, Y., & Wu, X. Y. (2007). Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles. Advanced Drug Delivery Reviews, 59(6), 491-504. 
  13. Liu, J., Meisner, D., Kwong, E., Wu, X. Y., & Johnston, M. R. (2007). A novel trans-lymphatic drug delivery system: Implantable gelatin sponge impregnated with PLGA-paclitaxel microspheres. Biomaterials, 28(21), 3236-3244. 
  14. Wong, H. L., Rauth, A. M., Bendayan, R., & Wu, X. Y. (2007). In vivo evaluation of a new polymer-lipid hybrid nanoparticle (PLN) formulation of doxorubicin in a murine solid tumor model. European Journal of Pharmaceutics and Biopharmaceutics, 65(3), 300-308. 
  15. Wong, H. L., Bendayan, R., Rauth, A. M., & Wu, X. Y. (2006). Simultaneous delivery of doxorubicin and GG918 (elacridar) by new polymer-lipid hybrid nanoparticles (PLN) for enhanced treatment of multidrug-resistant breast cancer. Journal of Controlled Release, 116(3), 275-284.
  16. Wong H.L., Li Y., Bendayan R., Rauth A.M., Wu X.Y. (2006) Solid lipid nanoparticles for cancer chemotherapy, in: Nanotechnology for Cancer Therapy, CRC Press, pp.714-776 (on invitation).
  17. Li, Y., Taulier, N., Rauth, A. M., & Wu, X. Y. (2006). Screening of lipid carriers and characterization of drug-polymer-lipid interactions for the rational design of polymer-lipid hybrid nanoparticles (PLN). Pharmaceutical Research, 23(8), 1877-1887. 
  18. Abdekhodaie, M. J., & Wu, X. Y. (2006). Drug loading onto ion-exchange microspheres: Modeling study and experimental verification. Biomaterials, 27(19), 3652-3662. 
  19. Wong, H. L., Rauth, A. M., Bendayan, R., Manias, J. L., Ramaswamy, M., Liu, Z., et al. (2006). A new polymer-lipid hybrid nanoparticle system increases cytotoxicity of doxorubicin against multidrug-resistant human breast cancer cells. Pharmaceutical Research, 23(7), 1574-1585. 
  20. Cheung, R. Y., Rauth, A. M., Ronaldson, P. T., Bendayan, R., & Wu, X. Y. (2006). In vitro toxicity to breast cancer cells of microsphere-delivered mitomycin C and its combination with doxorubicin. European Journal of Pharmaceutics and Biopharmaceutics, 62(3), 321-331. 
  21. Liu, J., Wong, H. -., Moselhy, J., Bowen, B., Wu, X. Y., & Johnston, M. R. (2006). Targeting colloidal particulates to thoracic lymph nodes. Lung Cancer, 51(3), 377-386. 
  22. Cheung, R. Y., Ying, Y., Rauth, A. M., Marcon, N., & Wu, X. Y. (2005). Biodegradable dextran-based microspheres for delivery of anticancer drug mitomycin C. Biomaterials, 26(26), 5375-5385. 
  23. Abdekhodaie, M. J., & Wu, X. Y. (2005). Modeling of a cationic glucose-sensitive membrane with consideration of oxygen limitation. Journal of Membrane Science, 254(1-2), 119-127.
  24. Cheung, R. Y., Rauth, A. M., & Wu, X. Y. (2005). In vivo efficacy and toxicity of intratumorally delivered mitomycin C and its combination with doxorubicin using microsphere formulations. Anti-Cancer Drugs, 16(4), 423-433. 
  25. Li, Y., Rauth, A. M., & Wu, X. Y. (2005). Prediction of kinetics of doxorubicin release from sulfopropyl dextran ion-exchange microspheres using artificial neural networks. European Journal of Pharmaceutical Sciences, 24(5), 401-410. 
  26. Zhou, Y., Chu, J. S., Zhou, T., & Wu, X. Y. (2005). Modeling of dispersed-drug release from two-dimensional matrix tablets. Biomaterials, 26(8), 945-952.
  27. Cheung, R. Y., Kuba, R., Rauth, A. M., & Wu, X. Y. (2004). A new approach to the in vivo and in vitro investigation of drug release from locoregionally delivered microspheres. Journal of Controlled Release, 100(1), 121-133. 
  28. Zhang, K., & Wu, X. Y. (2004). Temperature and pH-responsive polymeric composite membranes for controlled delivery of proteins and peptides. Biomaterials, 25(22), 5281-5291. 
  29. Wong, H. L., Bendayan, R., Rauth, A. M., & Wu, X. Y. (2004). Development of solid lipid nanoparticles containing ionically complexed chemotherapeutic drugs and chemosensitizers. Journal of Pharmaceutical Sciences, 93(8), 1993-2008. 
  30. Wu, Z. H., Sun, M., Mei, X. Y., & Ruda, H. E. (2004). Growth and photoluminescence characteristics of AlGaAs nanowires. Applied Physics Letters, 85(4), 657-659. 
  31. ZHang, K., Huang, H., Yang, G., Shaw, J., Yip, C., & Wu, X. Y. (2004). Characterization of nanostructure of stimuli-responsive polymeric composite membranes. Biomacromolecules, 5(4), 1248-1255. 
  32. Zhou, Y., Chu, J. S., & Wu, X. Y. (2004). Theoretical analysis of drug release into a finite medium from sphere ensembles with various size and concentration distributions. European Journal of Pharmaceutical Sciences, 22(4), 251-259. 
  33. Zhang, K., Quan, C., Huang, H., Taulier, N., & Wu, X. Y. (2004). On the stability of insulin delivered through a new glucose-responsive polymeric composite membrane. Journal of Pharmacy and Pharmacology, 56(5), 611-620. 
  34. Liu, Z., Ballinger, J. R., Rauth, A. M., Bendayan, R., & Wu, X. Y. (2003). Delivery of an anticancer drug and a chemosensitizer to murine breast sarcoma by intratumoral injection of sulfoprophyl dextran microspheres. Journal of Pharmacy and Pharmacology, 55(8), 1063-1073.
  35. Wu X.Y. and Yam F., Polymer system for drug delivery and solute separation, US patent No. 6,565,872 (May 2003).
  36. Zhou, Y., & Wu, X. Y. (2003). Modeling and analysis of dispersed-drug release into a finite medium from sphere ensembles with a boundary layer. Journal of Controlled Release, 90(1), 23-36. 
  37. Wu X.Y., Zhang Q. and Arshady R. (2003) Stimuli Sensitive Hydrogels. Polymer Structure and Phase Transition (invited review chapter) in: Polymeric Biomaterials, R. Arshady (Ed.), Citus Books, London, UK, p157-194.
  38. Wu X.Y., Zhang Q. and Arshady R. (2003) Stimuli Sensitive Hydrogels. Response and Release Modulation (invited review chapter) in: Polymeric Biomaterials, R. Arshady (Ed.), Citus Books, London, UK, p195-231.
  39. Zhou, Y., & Wu, X. Y. (2002). Theoretical analyses of dispersed-drug release from planar matrices with a boundary layer in a finite medium. Journal of Controlled Release, 84(1-2), 1-13. 
  40. Zhang, K., & Wu, X. Y. (2002). Modulated insulin permeation across a glucose-sensitive polymeric composite membrane. Journal of Controlled Release, 80(1-3), 169-178. 
  41. Liu, Z., Cheung, R., Wu, X. Y., Ballinger, J. R., Bendayan, R., & Rauth, A. M. (2001). A study of doxorubicin loading onto and release from sulfopropyl dextran ion-exchange microspheres. Journal of Controlled Release, 77(3), 213-224. 
  42. Liu, Z., Bendayan, R., & Wu, X. Y. (2001). Triton-X-100-modified polymer and microspheres for reversal of multidrug resistance. Journal of Pharmacy and Pharmacology, 53(6), 779-787. 
  43. Yam, F., Wu, X. Y., & Zhang, Q. (2000). A novel composite membrane for temperature-and pH-responsive permeation 
  44. Lenet, B. J., Komorowski, R., Wu, X. Y., Huang, J., Grad, H., Lawrence, H. P., et al. (2000). Antimicrobial substantivity of bovine root dentin exposed to different chlorhexidine delivery vehicles. Journal of Endodontics, 26(11), 652-655. 
  45. Liu, Z., Wu, X. Y., Ballinger, J. R., & Bendayan, R. (2000). Synthesis and characterization of surface-hydrophobic ion-exchange microspheres and the effect of coating on drug release rate. Journal of Pharmaceutical Sciences, 89(6), 807-817.
  46. Huang, J., Wong, H. -., Zhou, Y., Wu, X. Y., Grad, H., Komorowski, R., et al. (2000). In vitro studies and modeling of a controlled-release device for root canal therapy. Journal of Controlled Release, 67(2-3), 293-307. 
  47. Huang, J., Kao, H., & Wu, X. Y. (2000). The pH-dependent biphasic release of azidothymidine from a layered composite of PVA disks and P(MMA/MAA) spheres. Journal of Controlled Release, 67(1), 45-54. 
  48. Komorowski, R., Grad, H., Wu, X. Y., & Friedman, S. (2000). Antimicrobial substantivity of chlorhexidine-treated bovine root dentin. Journal of Endodontics, 26(6), 315-317. 
  49. Moselhy, J., Wu, X. Y., Nicholov, R., & Kodaria, K. (2000). In vitro studies of the interaction of poly(NIPAm/MAA) nanoparticles with proteins and cells. Journal of Biomaterials Science, Polymer Edition, 11(2), 123-147. 
  50. Li, J. -., Zhou, Y., Wu, X. Y., Odidi, I., & Odidi, A. (2000). Characterization of wet masses of pharmaceutical powders by triaxial compression test. Journal of Pharmaceutical Sciences, 89(2), 178-190. 
  51. Wu, X. Y., & Lee, P. I. (2000). Preparation and characterization of inulin ester microspheres as drug carriers. Journal of Applied Polymer Science, 77(4), 833-840. 
  52. Q. Zhang, L. Liu, X.Y. Wu, K. Yao (2000) pH-responsive swelling behavior of collagen complex materials, Art. Cells Blood Subs. Immob. Biotech. 28, 255-262.
  53. F. Yam, X.Y. Wu and Q. Zhang (2000) A novel composite membrane for temperature and pH responsive permeation, in: Controlled Drug Delivery: Designing Technology for the Future, Ed. K. Park, ACS, Washington, DC, pp. 263-272.
  54. Y. Sun, H. Zhou, Q. Zhang, X.Y. Wu (2000) Improved controlled release study of lomustine, Art. Cell, Blood Subs. Immob. Biotech. 28, 173-180.
  55. Wu, X. Y., & Zhou, Y. (1999). Studies of diffusional release of a dispersed solute from polymeric matrixes by finite element method. Journal of Pharmaceutical Sciences, 88(10), 1050-1057. 
  56. Huang, J., & Wu, X. Y. (1999). Effects of pH, salt, surfactant and composition on phase transition of poly(NIPAm/MAA) nanoparticles. Journal of Polymer Science, Part A: Polymer Chemistry, 37(14), 2667-2676. 
  57. Ly, J., & Wu, X. Y. (1999). Bimodal release of theophylline from 'seed-matrix' beads made of acrylic polymers. Pharmaceutical Development and Technology, 4(2), 257-267. 
  58. Liu, Z., Wu, X. Y., & Bendayan, R. (1999). In vitro investigation of ionic polysaccharide microspheres for simultaneous delivery of chemosensitizer and antineoplastic agent to multidrug-resistant cells. Journal of Pharmaceutical Sciences, 88(4), 412-418. 
  59. Wu, X. Y., & Zhou, Y. (1999). Simulation of diffusional release of a dispersed solute from polymeric matrices into a finite volume. Proceedings of the Controlled Release Society, (26), 1016-1017. 
  60. Yam F. and Wu X.Y. (1999) A novel composite membrane for temperature responsive permeation, Polymer Preprint, 40, 312-313.
  61. Wu, X. Y., Eshun, G., & Zhou, Y. (1998). Effect of interparticulate interaction on release kinetics of microsphere ensembles. Journal of Pharmaceutical Sciences, 87(5), 586-593. 
  62. Wu, X. Y., & Zhou, Y. (1998). Finite element analysis of diffusional drug release from complex matrix systems. II. factors influencing release kinetics. Journal of Controlled Release, 51(1), 57-71.
  63. Wu, X. Y., & Zhou, Y. (1998). Numerical analysis of drug release from matrix tablets with moving boundaries. Proceedings of the Controlled Release Society, (25), 451-452. 
  64. Wu, X. Y., Zhou, Y., & Eshun, G. (1998). Influence of drug accumulation and particle separation on release kinetics of multiparticulate systems. Proceedings of the Controlled Release Society, (25), 449-450. 
  65. Wu, X. Y., Ly, J., & Zhou, Y. (1998). Modeling of bimodal release from composite polymeric beads. Proceedings of the Controlled Release Society, (25), 447-448. 
  66. Huang, J., Wong, H. L., Wu, X. Y., Grad, H. A., Komorowski, R., & Friedman, S. (1998). A device for controlled release of antibacterial drugs for dental root canal therapy. Proceedings of the Controlled Release Society, (25), 778-779. 
  67. Zhou, Y., & Wu, X. Y. (1997). Finite element analysis of diffusional drug release from complex matrix systems. I. complex geometries and composite structures. Journal of Controlled Release, 49(2-3), 277-288.
  68. Subotic, D. V., & Wu, X. Y. (1997). Interactions of poly(N-isopropylacrylamide-co-methacrylic acid) with poly(N-vinylpyrrolidone). Industrial and Engineering Chemistry Research, 36(4), 1302-1309. 
  69. Pelton R.H., Wu X.Y., McPhee W., and Tam K.C., The preparation and characterization of polyNIPAM latexes, in: Colloidal polymer particles, Ed. J.W. Goodwin and R. Buscall, Academic Press, pp.81-99 (1995).
  70. Wu X.Y., Pelton R.H., Hamielec A.E., Woods D.R., and McPhee W., The kinetics of poly(N-isopropylacrylamide) microgel latex formation,  Colloid Polym. Sci. 272, 467-477 (1994).
  71. Hunkeler D., Wu X.Y. and Hamielec A.E., Pelton R.H., and Woods D.R., Characterization of polyacrylamide-co-sodium acrylate, in: Macro-Ion Characterization, From Dilute Solutions to Complex Fluids, Ed. K.S. Schmitz, pp.162-177 (1994).
  72. Wu, X. Y., & Lee, P. I. (1993). Preparation and characterization of thermal- and pH-sensitive nanospheres. Pharmaceutical Research, 10(10), 1544-1547. 
  73. Wu X.Y., Pelton R.H., Tam K.C., Woods D.R., and Hamielec A.E. Poly(N-isopropylacrylamide). I. Interactions with sodium dodecyl sulphate measured by conductivity, J. Polym. Sci.: Part A: Polym. Chem. 31, 957-962 (1993). 
  74. Tam K.C., Wu X.Y., and Pelton R.H., Poly(N-isopropylacrylamide). II. Effect of polymer concentration, temperature, and surfactant on the viscosity of aqueous solutions, J. Polym. Sci.: Part A: Polym. Chem., 31, 963-969 (1993). 
  75. Hunkeler D., Wu X.Y. and Hamielec A.E., Molecular weight characterization of poly(acrylamide-co-sodium acrylate) II. Light scattering, J. Appl. Polym. Sci. 46, 649-657 (1992). 
  76. Tam K.C., Wu X.Y. and Pelton R.H., Viscometry - A useful tool for studying conformational changes of poly(N-isopropylacrylamide) in solutions, Polymer Communications, 33, 436-438 (1992). 
  77. Hunkeler D., Wu X.Y. and Hamielec A.E., Characterization of polyelectrolytes, in: Polyelectrolyte Gels, Properties, Preparation, and Applications, Ed. R.S. Harland and R.K. Prud'homme, pp.53-79 (1992).
  78. Wu X.Y., Hunkeler D., Hamielec A.E., Pelton R.H. and Woods D.R., Molecular weight characterization of poly(acrylamide-co-sodium acrylate)  I. Viscometry, J. Appl. Polym. Sci. 42, 2081-2093 (1991). 
  79. Wu X.Y., Hunkeler D., Hamielec A.E. and Pelton R., Molecular weight characterization of polyelectrolytes, Polymer Materials Sci. Eng. 58, 792-794 (1988).
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Book Chapters

Patents & Copyrights

  • X.Y. Wu and F. Yam, CA patent No. 2,262,073 (issued in March 2009) Polymeric System for Drug Delivery and Solute Separation.
  • J. Liu, M. Johnston, X.Y. Wu, PCT/CA2006/001321 Methods and devices for lymphatic targeting (PCT Application).
  • J. Liu, M. Johnston, X.Y. Wu, US 12/063,614. Methods and devices for lymphatic targeting (USA).
  • J. Liu, M. Johnston, X.Y. Wu, CA 2,618,807 Methods and devices for lymphatic targeting (Canada).
  • J. Liu, M. Johnston, X.Y. Wu, EP2006000775100 (Publication# EP1922094A1) Methods and devices for lymphatic targeting (Europe).
  • J. Liu, M. Johnston, X.Y. Wu, CN200680038249.5 Methods and devices for lymphatic targeting (China).
  • J. Liu, M. Johnston, X.Y. Wu, IN 2108/DELNP/2008 Methods and devices for lymphatic targeting (India).
  • J. Liu, M. Johnston, X.Y. Wu, 200680038249.5 Methods and devices for lymphatic targeting (Hong Kong).
  • J. Liu, M. Johnston, X.Y. Wu, US60/707,534 Lymphatic Targeting (US Provisional Application).
  • X.Y. Wu, C. Gordijo, K. Zhang, H. Huang, US 61/331,690 Insulin delivery device (US Provisional Application).