Research Overview

Led by Professor Shirley (Xiao Yu) Wu, our research is centered on advanced pharmaceutics and drug delivery technologies. The goal of our research is to develop novel drug delivery strategies and systems to enhance treatment of major diseases such as cancer & diabetes.
​
Innovative approaches have been undertaken to achieve this goal by integrating multidisciplinary techniques and knowledge including micro- and nanotechnology, chemistry, computer simulation, engineering, pharmaceutics, pharmacology, and oncology. Our research program is highly interdisciplinary which bridges bio-sciences, materials sciences, physical sciences with clinical applications.  

Recent News

We would like to thank our past and present funders and partners:

Recent Publications

Picture
  1. Lugtu-Pe, J.A., Lin, B.Y., Chen, K., Ghaffari, A., Kane, A., Wu, X.Y., 2021. Tailoring Release Profiles of BCS Class II Drugs Using Controlled Release Amorphous Solid Dispersion Beads with Membrane-Reservoir Design: Effect of Pore Former and Coating Levels. Molecular Pharmaceutics. https://pubs.acs.org/doi/full/10.1021/acs.molpharmaceut.1c00623
Picture
  1. Ahmed, T., Liu, F.-C.F., He, C., Abbasi, A.Z., Cai, P., Rauth, A.M., Henderson, J.T., Wu, X.Y., 2021. Optimizing the design of blood–brain barrier-penetrating polymer-lipid-hybrid nanoparticles for delivering anticancer drugs to glioblastoma. Pharmaceutical Research. doi:10.1007/s11095-021-03122-9 
Picture
  1. GhavamiNejad, A., Lu, B., Samarikhalaj, M., Liu, J. F., Mirzaie, S., Pereira, S., . . . Wu, X. Y. 2021. Transdermal delivery of a somatostatin receptor type 2 antagonist using microneedle patch technology for hypoglycemia prevention. Drug Delivery and Translational Research. doi:10.1007/s13346-021-00944-3
Picture
  1. He, C., Ahmed, T., Abbasi, A.Z., Li, L.Y., Foltz, W.D., Cai, P., Knock, E., Fraser, P.E., Rauth, A.M., Henderson, J.T., Wu, X.Y., 2020. Multifunctional bioreactive-nanoconstructs for sensitive and accurate MRI of cerebrospinal fluid pathology and intervention of Alzheimer's disease. Nanotoday,doi:10.1016/j.nantod.2020.100965.
Picture

​Alves, S.R., Colquhoun, A., Wu, X.Y., Silva, D.de O., 2019. Synthesis of terpolymer-lipid encapsulated diruthenium(II,III)-anti-inflammatory metallodrug nanoparticles to enhance activity against glioblastoma cancer cells. Journal of Inorganic Biochemistry.
Picture
  1. Zhang, T., Lip, H., He, C., Cai, P., Wang, Z., Henderson, J.T., Rauth, A.M., Wu, X.Y., (2019) Multitargeted Nanoparticles Deliver Synergistic Drugs across the Blood–Brain Barrier to Brain Metastases of Triple Negative Breast Cancer Cells and Tumor‐Associated Macrophages. Advanced Healthcare Materials.