Research Overview

Led by Professor Shirley (Xiao Yu) Wu, our research is centered on advanced pharmaceutics and drug delivery technologies. The goal of our research is to develop novel drug delivery strategies and systems to enhance treatment of major diseases such as cancer & diabetes.
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Innovative approaches have been undertaken to achieve this goal by integrating multidisciplinary techniques and knowledge including micro- and nanotechnology, chemistry, computer simulation, engineering, pharmaceutics, pharmacology, and oncology. Our research program is highly interdisciplinary which bridges bio-sciences, materials sciences, physical sciences with clinical applications.  

Recent News

We would like to thank our past and present funders and partners:

Recent Publications

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Park, E., Li, L.Y., He, C., Abbasi, A.Z., Ahmed, T., Foltz, W.D., O'Flaherty, R., Zain, M., Bonin, R.P., Rauth, A.M., Fraser, P.E., Henderson, J.T., Wu, X.Y., 2023. Brain‐penetrating and disease site‐targeting manganese dioxide‐polymer‐lipid hybrid nanoparticles remodel microenvironment of alzheimer's disease by regulating multiple pathological pathways. Advanced Science.  
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  1. Chang, H.H.R., Chen, K., Lugtu-Pe, J.A., AL-Mousawi, N., Zhang, X., Bar-Shalom, D., Kane, A., Wu, X.Y., 2023. Design and optimization of a nanoparticulate pore former as a multifunctional coating excipient for ph transition-independent controlled release of weakly basic drugs for oral drug delivery. Pharmaceutics.
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  1. Ahmed, T., Liu, F.-C.F., Lu, B., Lip, H.Y., Park, E., Alradwan, I., Liu, J.F., He, C., Zetrini, A., Zhang, T., Ghavaminejad, A., Rauth, A.M., Henderson, J.T., Wu, X.Y., 2022. Advances in nanomedicine design: Multidisciplinary strategies for unmet medical needs. Molecular Pharmaceutics  doi:10.1021/acs.molpharmaceut.2c00038 
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Lu, B., GhavamiNejad, A., Liu, F. L., Li, J., Mirzaie, S., Giacca, A., Wu, X.Y., 2022: “Smart” Composite Microneedle Patch Stabilizes Glucagon and Prevents Nocturnal Hypoglycemia: Experimental Studies and Molecular Dynamics Simulation. ACS Appl. Mater. Interfaces. https://doi.org/10.1021/acsami.1c24955
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Lip, H.Y., Amini, M.A., Zetrini, A., Cai, P., Abbasi, A.Z., Bristow, R.G., Rauth, A.M., Wu, X.Y., 2022. Redox-responsive nanoparticles enhance radiation therapy by altering multifaceted radio-resistance mechanisms in human castration-resistant prostate cancer cells and xenografts. Radiotherapy and Oncology.