Research Overview

Led by Professor Shirley (Xiao Yu) Wu, our research is centered on advanced pharmaceutics and drug delivery technologies. The goal of our research is to develop novel drug delivery strategies and systems to enhance treatment of major diseases such as cancer & diabetes.
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Innovative approaches have been undertaken to achieve this goal by integrating multidisciplinary techniques and knowledge including micro- and nanotechnology, chemistry, computer simulation, engineering, pharmaceutics, pharmacology, and oncology. Our research program is highly interdisciplinary which bridges bio-sciences, materials sciences, physical sciences with clinical applications.  

Recent News

We would like to thank our past and present funders and partners:

Recent Publications

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Lu, B., GhavamiNejad, A., Liu, F. L., Li, J., Mirzaie, S., Giacca, A., Wu, X.Y., 2022: “Smart” Composite Microneedle Patch Stabilizes Glucagon and Prevents Nocturnal Hypoglycemia: Experimental Studies and Molecular Dynamics Simulation. ACS Appl. Mater. Interfaces. https://doi.org/10.1021/acsami.1c24955
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Lip, H.Y., Amini, M.A., Zetrini, A., Cai, P., Abbasi, A.Z., Bristow, R.G., Rauth, A.M., Wu, X.Y., 2022. Redox-responsive nanoparticles enhance radiation therapy by altering multifaceted radio-resistance mechanisms in human castration-resistant prostate cancer cells and xenografts. Radiotherapy and Oncology.
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  1. Zhang, R. X., Liu, F. F.-C., Lip, H., Liu, J., Zhang, Q., & Wu, X. Y., 2022. Pharmaceutical nanoformulation strategies to spatiotemporally manipulate oxidative stress for improving cancer therapies — exemplified by polyunsaturated fatty acids and other ROS-modulating agents. Drug Delivery and Translational Research. 
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  1. Lugtu-Pe, J.A., Lin, B.Y., Chen, K., Ghaffari, A., Kane, A., Wu, X.Y., 2021. Tailoring Release Profiles of BCS Class II Drugs Using Controlled Release Amorphous Solid Dispersion Beads with Membrane-Reservoir Design: Effect of Pore Former and Coating Levels. Molecular Pharmaceutics. 
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  1. Ahmed, T., Liu, F.-C.F., He, C., Abbasi, A.Z., Cai, P., Rauth, A.M., Henderson, J.T., Wu, X.Y., 2021. Optimizing the design of blood–brain barrier-penetrating polymer-lipid-hybrid nanoparticles for delivering anticancer drugs to glioblastoma. Pharmaceutical Research.