Research Overview

Led by Professor Shirley (Xiao Yu) Wu, our research is centered on advanced pharmaceutics and drug delivery technologies. The goal of our research is to develop novel drug delivery strategies and systems to enhance treatment of major diseases such as cancer & diabetes.
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Innovative approaches have been undertaken to achieve this goal by integrating multidisciplinary techniques and knowledge including micro- and nanotechnology, chemistry, computer simulation, engineering, pharmaceutics, pharmacology, and oncology. Our research program is highly interdisciplinary which bridges bio-sciences, materials sciences, physical sciences with clinical applications.  

Recent News

We would like to thank our past and present funders and partners:

Recent Publications

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  1. Zhang, T., Lip, H., He, C., Cai, P., Wang, Z., Henderson, J.T., Rauth, A.M., Wu, X.Y., (2019) Multitargeted Nanoparticles Deliver Synergistic Drugs across the Blood–Brain Barrier to Brain Metastases of Triple Negative Breast Cancer Cells and Tumor‐Associated Macrophages. Advanced Healthcare Materials.
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  1. GhavamiNejad, A., Li, J., Lu, B., Zhou, L., Lam, L., Giacca, A., Wu, X.Y., (2019) Glucose‐Responsive Composite Microneedle Patch for Hypoglycemia‐Triggered Delivery of Native Glucagon. Advanced Materials.
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  1. GhavamiNejad, A., Lu, B., Giacca, A., Wu, X.Y., (2019) Glucose regulation by modified boronic acid-sulfobetaine zwitterionic nanogels – a non-hormonal strategy for the potential treatment of hyperglycemia. Nanoscale 2019,11, 10167-10171.
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Thombre, A.G., Wu, X.Y.S., Ende, M.T.A., (2019) Controlled Release Technology And Design Of Oral Controlled Release Dosage Forms. Chemical Engineering in the Pharmaceutical Industry: Drug Product Design, Development, and Modeling, 2nd Edition, 381–407. 
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  1. Wang, Z., Zhang, R.X., Zhang, T., He, C., He, R., Ju, X., Wu, X.Y., (2018) In Situ Proapoptotic Peptide-Generating Rapeseed Protein-Based Nanocomplexes Synergize Chemotherapy for Cathepsin-B Overexpressing Breast Cancer. ACS Applied Materials & Interfaces.
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  1. Amini, M.A., Abbasi, A.Z., Cai, P., Lip, H., Gordijo, C.R., Li, J., Chen, B., Zhang, L., Rauth, A.M., Wu, X.Y., (2018) Combining Tumor Microenvironment Modulating Nanoparticles with Doxorubicin to Enhance Chemotherapeutic Efficacy and Boost Antitumor Immunity. JNCI: Journal of the National Cancer Institute.