The goal of our research is to develop novel drug delivery systems and treatment modalities to meet the unmet medical needs for treatment of cancer, diabetes, and CNS diseases. We undertake innovative and multidisciplinary approaches to achieve this goal by integrating the knowledge and technologies in nanotechnology, micro-technology, computer simulation, pharmaceutics, pharmacology, tumor biology, and molecular approaches. Our research program is highly interdisciplinary which bridges bio-sciences, material sciences, engineering and pharmaceutics with clinical applications. Our current research activities include
- Blood-brain barrier penetrating nanoparticle theranostics for brain cancer and CNS diseases;
- Nanomedicine of synergistic drug combinations for enhancing chemotherapy of multidrug resistant and metastatic cancer;
- Bioreactive hybrid nanoparticles for modulating tumor microenvironment and enhancing cancer therapies;
- Rational and computer-aided design of controlled release dosage forms;
- Stimulus-responsive polymers and nanotechnology-enabled closed-loop insulin delivery.