Led by Professor Shirley (Xiao Yu) Wu, our research is centered on advanced pharmaceutics and drug delivery technologies. The goal of our research is to develop novel drug delivery strategies and systems to enhance treatment of major diseases such as cancer & diabetes.
Innovative approaches have been undertaken to achieve this goal by integrating multidisciplinary techniques and knowledge including micro- and nanotechnology, chemistry, computer simulation, engineering, pharmaceutics, pharmacology, and oncology. Our research program is highly interdisciplinary which bridges bio-sciences, materials sciences, physical sciences with clinical applications.
Funding Agencies and Partners
Chen, K., Chang, H.H.R., Shalviri, A., Li, J., Lugtu-Pe, J.A., Kane, A., Wu, X.Y., 2017. Investigation of a New pH-responsive Nanoparticulate Pore Former for Controlled Release Enteric Coating with Improved Processability and Stability. European Journal of Pharmaceutics and Biopharmaceutics.
Rico, S.R.A., Abbasi, A.Z., Ribeiro, G., Ahmed, T., Wu, X.Y., Silva, D.D.O., 2017. Diruthenium(II,III) metallodrugs of ibuprofen and naproxen encapsulated in intravenously injectable polymer-lipid nanoparticles exhibit enhanced activity against breast and prostate cancer cells. Nanoscale.
Zhang, R.X., Li, L.Y., Li, J., Xu, Z., Abbasi, A.Z., Lin, L., Amini, M.A., Weng, W.Y., Sun, Y., Rauth, A.M., Wu, X.Y., 2017. Coordinating Biointeraction and Bioreaction of a Nanocarrier Material and an Anticancer Drug to Overcome Membrane Rigidity and Target Mitochondria in Multidrug-Resistant Cancer Cells. Advanced Functional Materials.
Li, J., Chu, M.K., Lu, B., Mirzaie, S., Chen, K., Gordijo, C.R., Plettenburg, O., Giacca, A., Wu, X.Y., 2017. Enhancing thermal stability of a highly concentrated insulin formulation with Pluronic F-127 for long-term use in microfabricated implantable devices. Drug Delivery and Translational Research.
Zhang, T., Prasad, P., Cai, P., He, C., Shan, D., Rauth, A.M., Wu, X.Y., 2017. Dual-targeted hybrid nanoparticles of synergistic drugs for treating lung metastases of triple negative breast cancer in mice. Acta Pharmacologica Sinica.
He, C., Cai, P., Li, J., Zhang, T., Lin, L., Abbasi, A. Z., Wu, X. Y., 2017. Blood-brain barrier-penetrating amphiphilic polymer nanoparticles deliver docetaxel for the treatment of brain metastases of triple negative breast cancer. Journal of Controlled Release 246, 98–109.